True Mac wizards keep their hands on the keys, and Apptivate can help, letting you assign hotkeys to open an application, file, folder, Automator script -- anything executable or openable. The menu bar app even blocks you if you're trying to use an established system-wide shortcut, like Command-C.
Plus you can enter hotkey sequences to prevent hand-twisting multikey simul-presses. What's easier, trying to press Command-Shift-Option-Control-2 all at once, or casually tapping a two-key combo (say, Option-E) then another letter? The latter, no question. And your hotkey sequences can get as long as you like.
We used F5 then one more letter to launch all of our most-used documents, and wound up ditching the Often Used Documents folder we had stashed in our Dock previously. Launching with a key combo is just so much more convenient than reaching for a mouse.
And if you get AppleScript or Automator involved, the possibilities are nearly endless, since Apptivate can launch a script that executes a whole series of steps. It took us all of 30 seconds to roll an Automator script to quit all applications and use Apptivate to map it to an F6, Q hotkey sequence. Apptivate's support website even has a few example scripts if you need ideas.
The bottom line. Apptivate keeps your fingers tappin' with hotkey-mappin'.
Positives
Menu bar interface. Hotkey sequences make it quite flexible.
Negatives
Can't access menus inside of your apps, only to open things.