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If you are using cron to start Folding@home (or for anything else), then you should backup your crontabs before installing Leopard.

You can backup your own crontab with this command:

crontab -l > ~/crontab_backup.txt

To restore your backup crontab after upgrading:

crontab ~/crontab_backup.txt

You may also want to backup your root crontab if you have edited it:

sudo crontab -l > ~/crontab_backup_root.txt

To restore your backup root crontab after upgrading:

sudo crontab ~/crontab_backup_root.txt